Elevated Resistin Gene Expression in African American Estrogen and Progesterone Receptor Negative Breast Cancer.

ABSTRACT:

Introduction

African American (AA) women diagnosed with breast cancer are more likely to have aggressive subtypes. Investigating differentially expressed genes between patient populations may help explain racial health disparities. Resistin, one such gene, is linked to inflammation, obesity, and breast cancer risk. Previous studies indicated that resistin expression is higher in serum and tissue of AA breast cancer patients compared to Caucasian American (CA) patients. However, resistin expression levels have not been compared between AA and CA patients in a stage- and subtype-specific context. Breast cancer prognosis and treatments vary by subtype. This work investigates differential resistin gene expression in human breast cancer tissues of specific stages, receptor subtypes, and

SUBMITTER: Vallega KA 

PROVIDER: S-EPMC4912107 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature