Ontology highlight
ABSTRACT:
SUBMITTER: Slichter CK
PROVIDER: S-EPMC4912124 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Slichter Chloe K CK McDavid Andrew A Miller Hannah W HW Finak Greg G Seymour Brenda J BJ McNevin John P JP Diaz Gabriela G Czartoski Julie L JL McElrath M Juliana MJ Gottardo Raphael R Prlic Martin M
JCI insight 20160601 8
Conventional memory CD8<sup>+</sup> T cells and mucosal-associated invariant T cells (MAIT cells) are found in blood, liver, and mucosal tissues and have similar effector potential following activation, specifically expression of IFN-γ and granzyme B. To better understand each subset's unique contributions to immunity and pathology, we interrogated inflammation- and TCR-driven activation requirements using human memory CD8<sup>+</sup> T and MAIT cells isolated from blood and mucosal tissue biops ...[more]