Validation of candidate genes associated with cardiovascular risk factors in psychiatric patients.
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ABSTRACT:
SUBMITTER: Windemuth A
PROVIDER: S-EPMC4912220 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Publications
Validation of candidate genes associated with cardiovascular risk factors in psychiatric patients.
Windemuth Andreas A de Leon Jose J Goethe John W JW Schwartz Harold I HI Woolley Stephen S Susce Margaret M Kocherla Mohan M Bogaard Kali K Holford Theodore R TR Seip Richard L RL Ruaño Gualberto G
Progress in neuro-psychopharmacology & biological psychiatry 20110806 2
The purpose of this study was to identify genetic variants predictive of cardiovascular risk factors in a psychiatric population treated with second generation antipsychotics (SGA). 924 patients undergoing treatment for severe mental illness at four US hospitals were genotyped at 1.2 million single nucleotide polymorphisms. Patients were assessed for fasting serum lipid (low density lipoprotein cholesterol [LDLc], high density lipoprotein cholesterol [HDLc], and triglycerides) and obesity phenot ...[more]
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