Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs.

ABSTRACT: The development of small molecules that target RNA is challenging yet, if successful, could advance the development of chemical probes to study RNA function or precision therapeutics to treat RNA-mediated disease. Previously, we described Inforna, an approach that can mine motifs (secondary structures) within target RNAs, which is deduced from the RNA sequence, and compare them to a database of known RNA motif-small molecule binding partners. Output generated by Inforna includes the motif found in both the database and the desired RNA target, lead small molecules for that target, and other related meta-data. Lead small molecules can then be tested for binding and affecting cellular (dys)function. Herein, we describe Inforna 2.0, which incorporates all known RNA motif-small molecule binding

SUBMITTER: Disney MD 

PROVIDER: S-EPMC4912454 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature