Functional Gonadotroph Adenomas: Case Series and Report of Literature.

ABSTRACT:

Background

Functional gonadotroph adenomas (FGAs) are rare tumors of the pituitary gland that secrete biologically active gonadotropins.

Objective

To advance clinical understanding of FGAs.

Methods

We performed a retrospective review of adult patients who underwent resection of a pituitary lesion between August 1997 and October 2014 and remain under care at our center. We identified patients who had pathologic and biochemical confirmation of FGAs, as defined by a lack of serum follicle-stimulating hormone/luteinizing hormone suppression in the setting of elevated gonadal steroids, associated clinical symptoms, or both.

Results

FGAs were documented in 7 patients (5 men, 2 women) over a 17-year period. Clinical findings at presentation included visual field defic

SUBMITTER: Cote DJ 

PROVIDER: S-EPMC4912468 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature