Epidemiological and economic burden of Clostridium difficile in the United States: estimates from a modeling approach.

ABSTRACT:

Background

Despite a large increase in Clostridium difficile infection (CDI) severity, morbidity and mortality in the US since the early 2000s, CDI burden estimates have had limited generalizability and comparability due to widely varying clinical settings, populations, or study designs.

Methods

A decision-analytic model incorporating key input parameters important in CDI epidemiology was developed to estimate the annual number of initial and recurrent CDI cases, attributable and all-cause deaths, economic burden in the general population, and specific number of high-risk patients in different healthcare settings and the community in the US. Economic burden was calculated adopting a societal perspective using a bottom-up approach that identified healthcare resources consumed

SUBMITTER: Desai K 

PROVIDER: S-EPMC4912810 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature