Human metapneumovirus epidemiological and evolutionary patterns in Coastal Kenya, 2007-11.

ABSTRACT:

Background

Human metapneumovirus (HMPV) is an important global cause of severe acute respiratory infections in young children and the elderly. The epidemiology of HMPV in sub-Saharan Africa is poorly described and factors that allow its recurrent epidemics in communities not understood.

Methods

We undertook paediatric inpatient surveillance for HMPV in Kilifi County Hospital (KCH) of Coastal Kenya between 2007 and 2011. Nasopharyngeal samples collected from children aged 1 day-59 months admitted with severe or very severe pneumonia, were tested for HMPV using real-time polymerase chain reaction (RT-PCR). Partial nucleotide sequences of the attachment (G) and fusion (F) surface proteins of positive samples were determined and phylogenetically analyzed.

Results

HMPV was

SUBMITTER: Owor BE 

PROVIDER: S-EPMC4912817 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature