Targeting inflammation as a treatment modality for neuropathic pain in spinal cord injury: a randomized clinical trial.

ABSTRACT:

Background

The purpose of the present study was to examine the effectiveness of an anti-inflammatory intervention as a treatment for neuropathic pain following spinal cord injury (SCI).

Methods

This randomized, parallel-group, controlled clinical trial (NCT02099890) examined 20 participants with varying levels and severities of SCI, randomized (3:2) to either a 12-week anti-inflammatory diet, or control group. Outcome measures consisted of self-determined indices of pain as assessed using the neuropathic pain questionnaire (NPQ) and markers of inflammation as assessed by various pro- and anti-inflammatory cytokines, as well as the eicosanoids PGE2 and LTB4.

Results

A significant group × time interaction was found for sensory pain scores (p < 0.01). A Mann-Whitney test

SUBMITTER: Allison DJ 

PROVIDER: S-EPMC4912827 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature