Rates and predictors of progression to esophageal carcinoma in a large population-based Barrett's esophagus cohort.

ABSTRACT:

Background and aims

Rates of progression to esophageal adenocarcinoma in subjects with Barrett's esophagus (BE) are lower than previously estimated. Identification of predictors of progression will enable risk stratification of BE subjects, potentially making current surveillance programs more efficient. We aimed to assess the potential of demographic and lifestyle factors, obesity, and medications in predicting progression in BE.

Methods

BE subjects were identified from the General Practice Research Database using validated diagnostic codes. BE subjects developing esophageal cancer (EC) 12 months after their index BE diagnosis were defined as progressors. Time-to-event analysis was used to assess the overall risk of progression to EC. Cox proportional hazards models and tim

SUBMITTER: Krishnamoorthi R 

PROVIDER: S-EPMC4912845 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature