Functional and morphological alterations of the urinary bladder in type 2 diabetic FVB(db/db) mice.

ABSTRACT:

Aims

Diabetic bladder dysfunction (DBD) has been extensively studied in animal models of type 1 diabetes. We aimed to examine the functional and morphological alterations of the urinary bladder in a type 2 diabetes model, FVB(db/db) mice.

Methods

FVB(db/db) mice and age-matched FVB/NJ control mice were tested at either 12, 24 or 52weeks of age. Body weight, blood glucose and glycated hemoglobin (HbA1c) levels were measured. Bladder function was assessed by measurement of 24-h urination behavior and conscious cystometry. Bladder was harvested for Masson's Trichrome staining and morphometric analysis.

Results

The body weights of FVB(db/db) mice were twice as those of FVB/NJ control mice. The blood glucose and HbA1c levels were higher in FVB(db/db) mice at 12 and 24weeks

SUBMITTER: Wu L 

PROVIDER: S-EPMC4912852 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature