Psoriasiform eruptions during Kawasaki disease (KD): A distinct phenotype.

ABSTRACT:

Background

A psoriasis-like eruption develops in a subset of patients with Kawasaki disease (KD).

Objective

We sought to systematically compare KD-associated psoriasiform eruptions with classic psoriasis and the outcomes of KD in children with and without this rash.

Methods

This was a retrospective study of 11 KD cases with a psoriasiform eruption matched 1:2 by age, gender, and ethnicity with psoriasis-only and KD-only controls. Genotyping was performed in 10 cases for a deletion of 2 late cornified envelope (LCE) genes, LCE3C_LCE3B-del, associated with increased risk for pediatric-onset psoriasis.

Results

Similar to classic psoriasis, KD-associated eruptions were characterized clinically by well-demarcated, scaly pink plaques and histopathologically by intrae

SUBMITTER: Haddock ES 

PROVIDER: S-EPMC4912865 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature