Severe hypoglycemia in the Look AHEAD Trial.

ABSTRACT:

Objective

The Look AHEAD trial was a multi-center, randomized controlled trial, to determine whether weight loss reduces cardiovascular morbidity and mortality in overweight individuals with type 2 diabetes. The objective of this study was to evaluate the incidence of severe hypoglycemia in patients enrolled in Look AHEAD. Research Design and Methods 5,145 subjects were randomized to diabetes support and education (DSE) or intensive lifestyle intervention (ILI). Instances of severe hypoglycemia were recorded. Regression analysis was used to compare the development of severe hypoglycemia between groups.

Results

Over the entire study, the severe hypoglycemia rate was not different between ILI and DSE groups (0.49 ILI, 0.51 DSE/100 person-years, rate ratio=1.12, p=0.41), but wa

SUBMITTER: Look AHEAD Research Group (Appendix A) 

PROVIDER: S-EPMC4912885 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature