Cardiovascular autonomic neuropathy associates with nephropathy lesions in American Indians with type 2 diabetes.

ABSTRACT:

Aims

Cardiovascular autonomic neuropathy (CAN) predicts clinical diabetic nephropathy (DN). We investigated the relationship between DN structural lesions and CAN.

Methods

Sixty three Pima Indians with type 2 diabetes underwent kidney biopsies following a 6-year clinical trial testing the renoprotective efficacy of losartan vs. placebo. CAN was assessed a median 9.2years later. CAN variables included expiration/inspiration ratio (E/I), standard deviation of the normal R-R interval (sdNN), and low and high frequency signal power and their ratio (LF, HF, LF/HF); lower values reflect more severe neuropathy. Associations of CAN with renal structural variables were assessed by linear regression adjusted for age, sex, diabetes duration, blood pressure, HbA1c, glomerular filtration

SUBMITTER: Wheelock KM 

PROVIDER: S-EPMC4912901 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature