Osteosarcoma: Cells-of-Origin, Cancer Stem Cells, and Targeted Therapies.

ABSTRACT: Osteosarcoma (OS) is the most common type of primary solid tumor that develops in bone. Although standard chemotherapy has significantly improved long-term survival over the past few decades, the outcome for those patients with metastatic or recurrent OS remains dismally poor and, therefore, novel agents and treatment regimens are urgently required. A hypothesis to explain the resistance of OS to chemotherapy is the existence of drug resistant CSCs with progenitor properties that are responsible of tumor relapses and metastasis. These subpopulations of CSCs commonly emerge during tumor evolution from the cell-of-origin, which are the normal cells that acquire the first cancer-promoting mutations to initiate tumor formation. In OS, several cell types along the osteogenic lineage have been p

SUBMITTER: Abarrategi A 

PROVIDER: S-EPMC4913005 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature