Resting-state networks distinguish locked-in from vegetative state patients.

ABSTRACT:

Purpose

Locked-in syndrome and vegetative state are distinct outcomes from coma. Despite their differences, they are clinically difficult to distinguish at the early stage and current diagnostic tools remain insufficient. Since some brain functions are preserved in locked-in syndrome, we postulated that networks of spontaneously co-activated brain areas might be present in locked-in patients, similar to healthy controls, but not in patients in a vegetative state.

Methods

Five patients with locked-in syndrome, 12 patients in a vegetative state and 19 healthy controls underwent a resting-state fMRI scan. Individual spatial independent component analysis was used to separate spontaneous brain co-activations from noise. These co-activity maps were selected and then classified by

SUBMITTER: Roquet D 

PROVIDER: S-EPMC4913176 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature