Maternal residential proximity to major roadways, birth weight, and placental DNA methylation.

ABSTRACT:

Background

Exposure to traffic pollution during fetal development has been associated with reduced fetal growth, and there is evidence to suggest that epigenetic mechanisms in the placenta in the form of variant DNA methylation may be a potential mechanism underlying this effect.

Objectives

To examine the association between residential proximity to nearest major roadway, as a marker of traffic-related pollution, fetal growth and placental DNA methylation.

Methods

We obtained residential addresses, placenta samples, and demographic data from 471 women following delivery of term infants. Using generalized linear models we evaluated the association between living close to a major roadway (defined as living ≤150m from a primary highway or primary road or ≤50m from a seco

SUBMITTER: Kingsley SL 

PROVIDER: S-EPMC4913202 | biostudies-literature | 2016 Jul-Aug

REPOSITORIES: biostudies-literature