Ontology highlight
ABSTRACT:
SUBMITTER: Wu X
PROVIDER: S-EPMC4913270 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Wu Xia X Song Miao M Yang Xi X Liu Xin X Liu Kun K Jiao Cuihua C Wang Jinze J Bai Chunling C Su Guanghua G Liu Xuefei X Li Guangpeng G
Scientific reports 20160620
Bovine embryonic stem cells (bESCs) have not been successfully established yet. One reason could be that CDX2, as the trophectoderm regulator, expresses in bovine inner cell mass (ICM), which probably becomes a technical barrier for maintaining the pluripotency of bESCs in vitro. We hypothesized that CDX2 knockdown (CDX2-KD) could remove such negative effort, which will be helpful for capturing complete and permanent capacity of pluripotency. Expression and localization of pluripotent genes were ...[more]