ORION: a web server for protein fold recognition and structure prediction using evolutionary hybrid profiles.

ABSTRACT: Protein structure prediction based on comparative modeling is the most efficient way to produce structural models when it can be performed. ORION is a dedicated webserver based on a new strategy that performs this task. The identification by ORION of suitable templates is performed using an original profile-profile approach that combines sequence and structure evolution information. Structure evolution information is encoded into profiles using structural features, such as solvent accessibility and local conformation -with Protein Blocks-, which give an accurate description of the local protein structure. ORION has recently been improved, increasing by 5% the quality of its results. The ORION web server accepts a single protein sequence as input and searches homologous protein structures w

SUBMITTER: Ghouzam Y 

PROVIDER: S-EPMC4913311 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature