ABO blood type and stroke risk: the REasons for Geographic And Racial Differences in Stroke Study.

ABSTRACT:

Background

ABO blood type is an inherited trait associated with coagulation factor levels and vascular outcomes.

Objectives

To assess the association of blood type with stroke and whether blood type contributes to racial disparities in stroke in the United States.

Patients and methods

The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study recruited 30 239 participants between 2003 and 2007. Using a case-cohort design, blood type was genotyped in 646 participants with stroke and a 1104-participant cohort random sample. Cox models that adjusted for Framingham stroke risk factors were used to assess the association of blood type with stroke.

Results

During 5.8 years of follow-up, blood types A or B vs. type O were not associated with stroke. B

SUBMITTER: Zakai NA 

PROVIDER: S-EPMC4913462 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature