Investigating the Microstructural Correlation of White Matter in Autism Spectrum Disorder.

ABSTRACT: White matter microstructure forms a complex and dynamical system that is critical for efficient and synchronized brain function. Neuroimaging findings in children with autism spectrum disorder (ASD) suggest this condition is associated with altered white matter microstructure, which may lead to atypical macroscale brain connectivity. In this study, we used diffusion tensor imaging measures to examine the extent that white matter tracts are interrelated within ASD and typical development. We assessed the strength of inter-regional white matter correlations between typically developing and ASD diagnosed individuals. Using hierarchical clustering analysis, clustering patterns of the pairwise white matter correlations were constructed and revealed to be different between the two groups. Additi

SUBMITTER: Dean DC 

PROVIDER: S-EPMC4913512 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature