Breast cancer recurrence in relation to antidepressant use.

ABSTRACT:

Purpose

Women with breast cancer frequently use antidepressants; however, questions about the effect of these medications on breast cancer recurrence remain.

Methods

We identified 4,216 women ≥18 years with an incident stage I or II breast cancer diagnosed between 1990 and 2008 in a mixed-model healthcare delivery system linked to a cancer registry. Recurrences were ascertained from chart review. Medication exposures were extracted from electronic pharmacy records. We used multivariable Cox proportional hazards models to estimate hazard ratios (HR) and 95 % confidence intervals (CI) to assess the association between antidepressant use and breast cancer recurrence and mortality. We also conducted analyses restricted to tamoxifen users.

Results

Antidepressants overall,

SUBMITTER: Chubak J 

PROVIDER: S-EPMC4913547 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature