Functional MRI of emotional memory in adolescent depression.

ABSTRACT:

Introduction

Major Depressive Disorder (MDD) is a leading cause of disease burden worldwide. Mood-congruent biases in memory tasks are frequently reported in MDD patients, with facilitated memory for negative stimuli. Most functional MRI studies to date have examined the neural correlates of these biases in depressed adults, with fewer studies in adolescents with MDD. Investigation of MDD in adolescence may aid greater understanding of the aetiology and development of the disorder.

Methods

Cognitive biases were investigated in 56 MDD patients aged 11-17 years and a matched group of 30 healthy control participants with a self-referential memory task. Behavioural performance and BOLD fMRI data were collected during both encoding and retrieval stages.

Results

The neural

SUBMITTER: Holt RJ 

PROVIDER: S-EPMC4913558 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature