New Insights in the Functional Zonation of the Canine Adrenal Cortex.

ABSTRACT:

Background

Current understanding of adrenal steroidogenesis is that the production of aldosterone or cortisol depends on the expression of aldosterone synthase (CYP11B2) and 11β-hydroxylase cytochrome P450 (CYP11B1), respectively. However, this has never been studied in dogs, and in some species, a single CYP11B catalyzes both cortisol and aldosterone formation. Analysis of the canine genome provides data of a single CYP11B gene which is called CYP11B2, and a large sequence gap exists near the so-called CYP11B2 gene.

Objectives

To investigate the zonal expression of steroidogenic enzymes in the canine adrenal cortex and to determine whether dogs have 1 or multiple CYP11B genes.

Animals

Normal adrenal glands from 10 healthy dogs.

Methods

Zona fasciculata (zF) an

SUBMITTER: Sanders K 

PROVIDER: S-EPMC4913559 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature