Comparison of Serum Spec fPL(™) and 1,2-o-Dilauryl-Rac-Glycero-3-Glutaric Acid-(6'-Methylresorufin) Ester Assay in 60 Cats Using Standardized Assessment of Pancreatic Histology.

ABSTRACT:

Background

Feline pancreas-specific lipase (Spec fPL) is considered a useful test for the antemortem diagnosis of pancreatitis in cats. A recent study found good agreement between the results of the Spec fPL and catalytic 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6'-methylresorufin) ester (DGGR) lipase assay. Prospective studies evaluating their sensitivity and specificity are lacking.

Objectives

To compare the results of the Spec fPL and the DGGR assays with a standardized histologic assessment of the pancreas.

Animals

Sixty client-owned cats presented for necropsy.

Methods

Prospective study

Spec fPL concentrations and serum DGGR lipase activity were measured from the same blood sample. The pancreas was removed within 3 hours after euthanasia; serial

SUBMITTER: Oppliger S 

PROVIDER: S-EPMC4913568 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature