Characterization of an Inherited Neurologic Syndrome in Toyger Cats with Forebrain Commissural Malformations, Ventriculomegaly and Interhemispheric Cysts.

ABSTRACT:

Background

In children, frequent congenital malformations with concomitant agenesis of the corpus callosum are diagnosed by neuroimaging in association with other cerebral malformations, including interhemispheric cysts and ventriculomegaly. Similar studies providing full characterization of brain defects by in vivo magnetic resonance imaging (MRI), and correlations with the pertinent anatomic pathologic examinations are absent in veterinary medicine.

Hypothesis/objectives

Congenital brain defects underlie the neurologic signs observed in Toyger cats selectively bred for a short ear phenotype.

Animals

Using proper pedigree analysis and genetic evaluations, 20 related Oriental-derived crossbred Toyger cats were evaluated. Seven clinically healthy (carrier) cats and 13

SUBMITTER: Keating MK 

PROVIDER: S-EPMC4913598 | biostudies-literature | 2016 Mar-Apr

REPOSITORIES: biostudies-literature