Correlation of Urine and Serum Biomarkers with Renal Damage and Survival in Dogs with Naturally Occurring Proteinuric Chronic Kidney Disease.

ABSTRACT:

Background

Urine protein loss is common in dogs with chronic kidney disease (CKD).

Hypothesis/objectives

To evaluate new biomarkers of glomerular and tubulointerstitial (TI) damage compared with histology and as survival indicators in dogs with naturally occurring, proteinuric CKD.

Animals

One hunderd and eighty dogs with naturally occurring kidney disease.

Methods

Retrospective study using urine, serum, and renal biopsies from dogs with kidney disease, 91% of which had proteinuric CKD. Biomarkers were evaluated and correlated with pathologic renal damage, and significant associations, sensitivities, and specificities of biomarkers for renal disease type were determined.

Results

Fractional excretions of immunogloblin M (IgM_FE) and immunoglobulin G (IgG_

SUBMITTER: Hokamp JA 

PROVIDER: S-EPMC4913609 | biostudies-literature | 2016 Mar-Apr

REPOSITORIES: biostudies-literature