Breed Distribution and Clinical Characteristics of B Cell Chronic Lymphocytic Leukemia in Dogs.

ABSTRACT:

Background

B-cell chronic lymphocytic leukemia (B-CLL) is the most common hematopoietic malignancy in humans in the developed world and the primary risk factor is genetic. Dogs also develop B-CLL, but there is no systematic description of the disease in dogs. Understanding the epidemiology of B-CLL in dogs may help practitioners recognize the disease and position the dog as a model for future genetic studies.

Objectives

To describe B-CLL presentation in dogs, its clinicopathologic findings, and breed predisposition.

Animals

Four hundred and ninety-one dogs with B-CLL and 5,673 control dogs with suspicion of a lymphoproliferative disorder (LPD).

Methods

Retrospective cross-sectional study of dogs for which samples were submitted to the Colorado State University

SUBMITTER: Bromberek JL 

PROVIDER: S-EPMC4913636 | biostudies-literature | 2016 Jan-Feb

REPOSITORIES: biostudies-literature