A Placebo-Controlled, Prospective, Randomized Clinical Trial of Polyethylene Glycol and Methylprednisolone Sodium Succinate in Dogs with Intervertebral Disk Herniation.

ABSTRACT:

Background

Acute intervertebral disk herniation (IVDH) is a common cause of spinal cord injury in dogs and currently there is no proven medical treatment to counter secondary injury effects. Use of methylprednisolone sodium succinate (MPSS) or polyethylene glycol (PEG) as neuroprotectants is advocated but controversial because neither treatment has been tested in placebo-controlled, randomized, blinded trials in dogs.

Hypothesis

Polyethylene glycol will improve the outcome of severe spinal cord injury caused by IVDH compared to MPSS or placebo.

Animals

Client-owned dogs with acute onset of thoracolumbar IVDH causing paralysis and loss of nociception for <24 hours.

Methods

Dogs were randomized to receive MPSS, PEG, or placebo; drugs appeared identical and group

SUBMITTER: Olby NJ 

PROVIDER: S-EPMC4913663 | biostudies-literature | 2016 Jan-Feb

REPOSITORIES: biostudies-literature