Evaluating cytology for the detection of invasive cervical cancer.

ABSTRACT:

Objective

To assess the sensitivity, the number needed to screen (NNS) and the positive predictive value (PPV) of cervical cytology for the diagnosis of cancer by age in a screening population.

Methods

A retrospective cohort of women with invasive cervical cancer nested within a census of cervical cytology. All (c. 8 million) women aged 20-64 years with cervical cytology (excluding tests after an earlier abnormality). From April 2007 to March 2010, 3372 women had cervical cancer diagnosed within 12 months of such cytology in England. The sensitivity of cervical cytology to cancer, NNS to detect one cancer and predictive values of cytology were calculated for various 'referral' thresholds. These were calculated for ages 20-24, 25-34, 35-49 and 50-64 years.

Results

The

SUBMITTER: Landy R 

PROVIDER: S-EPMC4913744 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature