Changes to the lateral geniculate nucleus in Alzheimer's disease but not dementia with Lewy bodies.

ABSTRACT:

Aims

Complex visual hallucinations occur in 70% of dementia with Lewy bodies (DLB) cases and significantly affect patient well-being. Visuo-cortical and retinal abnormalities have been recorded in DLB and may play a role in visual hallucinations. The present study aimed to investigate the lateral geniculate nucleus (LGN), a visual relay centre between the retina and visual cortex, to see if changes to this structure underlie visual hallucinations in DLB.

Methods

Fifty-one [17 probable DLB, 19 control and 15 probable Alzheimer's disease (AD)] cases were recruited for a functional magnetic resonance imaging study, in which patients' response to a flashing checkerboard stimulus was detected and measured in the LGN, before comparison across experimental groups. Additionally, pos

SUBMITTER: Erskine D 

PROVIDER: S-EPMC4913748 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature