Bioactivity-Guided Identification of Botanical Inhibitors of Ketohexokinase.

ABSTRACT:

Objective

In developed countries with westernized diets, the excessive consumption of added sugar in beverages and highly refined and processed foods is associated with increased risk for obesity, diabetes, and cardiovascular diseases. As a major constituent of added sugars, fructose has been shown to cause a variety of adverse metabolic effects, such as impaired insulin sensitivity, hypertriglyceridemia, and oxidative stress. Recent studies have shown that ketohexokinase isoform C is the key enzyme responsible in fructose metabolism that drive's fructose's adverse effects. The objective of this study was to identify botanical ingredients with potential for inhibitory activity against ketohexokinase-C and fructose-induced metabolic effects by using a series of in vitro model system

SUBMITTER: Le MT 

PROVIDER: S-EPMC4913896 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature