Age-related alterations in blood and colonic dendritic cell properties.

ABSTRACT:

Background

Dendritic cells (DC) determine initiation, type and location of immune responses and, in adults, show decreased Toll-like receptors and some increased cytokine levels on ageing. Few studies in children have characterised DC or explored DC-related mechanisms producing age-related immune changes.

Results

The pDC marker BDCA2 (but not CD123) was absent in pre-pubertal children and numbers of pDC decreased with age. Blood and colonic DC were more mature and activated in adults. Decrease in pDC numbers correlated with reduced GM-CSF levels with aging, but increasing IL-4 and IL-8 levels correlated with a more activated DC profile in blood. CXCL16 levels decreased with age.

Methods

Blood and colonic DC phenotypes were determined in healthy adults and children by

SUBMITTER: Vora R 

PROVIDER: S-EPMC4914258 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature