Circulating cellular adhesion molecules and risk of diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA).

ABSTRACT:

Aims

To test the hypothesis that soluble cellular adhesion molecules would be positively and independently associated with risk of diabetes.

Methods

Soluble levels of six cellular adhesion molecules (ICAM-1, E-selectin, VCAM-1, E-cadherin, L-selectin and P-selectin) were measured in participants in the Multi-Ethnic Study of Atherosclerosis, a prospective cohort study. Participants were then followed for up to 10 years to ascertain incident diabetes.

Results

Sample sizes ranged from 826 to 2185. After adjusting for age, sex, race/ethnicity, BMI and fasting glucose or HbA1c , four cellular adhesion molecules (ICAM-1, E-selectin, VCAM-1 and E-cadherin) were positively associated with incident diabetes and there was a statistically significant trend across quartiles. Comp

SUBMITTER: Pankow JS 

PROVIDER: S-EPMC4914403 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature