MEMO1 drives cranial endochondral ossification and palatogenesis.

ABSTRACT: The cranial base is a component of the neurocranium and has a central role in the structural integration of the face, brain and vertebral column. Consequently, alteration in the shape of the human cranial base has been intimately linked with primate evolution and defective development is associated with numerous human facial abnormalities. Here we describe a novel recessive mutant mouse strain that presented with a domed head and fully penetrant cleft secondary palate coupled with defects in the formation of the underlying cranial base. Mapping and non-complementation studies revealed a specific mutation in Memo1 - a gene originally associated with cell migration. Expression analysis of Memo1 identified robust expression in the perichondrium and periosteum of the developing cranial base, b

SUBMITTER: Van Otterloo E 

PROVIDER: S-EPMC4914435 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature