Ontology highlight
ABSTRACT:
SUBMITTER: Capellera-Garcia S
PROVIDER: S-EPMC4914771 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Capellera-Garcia Sandra S Pulecio Julian J Dhulipala Kishori K Siva Kavitha K Rayon-Estrada Violeta V Singbrant Sofie S Sommarin Mikael N E MN Walkley Carl R CR Soneji Shamit S Karlsson Göran G Raya Ángel Á Sankaran Vijay G VG Flygare Johan J
Cell reports 20160602 11
Erythroid cell commitment and differentiation proceed through activation of a lineage-restricted transcriptional network orchestrated by a group of well characterized genes. However, the minimal set of factors necessary for instructing red blood cell (RBC) development remains undefined. We employed a screen for transcription factors allowing direct lineage reprograming from fibroblasts to induced erythroid progenitors/precursors (iEPs). We show that Gata1, Tal1, Lmo2, and c-Myc (GTLM) can rapidl ...[more]