Novel Methodology for Characterizing Regional Variations in the Material Properties of Murine Aortas.

ABSTRACT: Many vascular disorders, including aortic aneurysms and dissections, are characterized by localized changes in wall composition and structure. Notwithstanding the importance of histopathologic changes that occur at the microstructural level, macroscopic manifestations ultimately dictate the mechanical functionality and structural integrity of the aortic wall. Understanding structure-function relationships locally is thus critical for gaining increased insight into conditions that render a vessel susceptible to disease or failure. Given the scarcity of human data, mouse models are increasingly useful in this regard. In this paper, we present a novel inverse characterization of regional, nonlinear, anisotropic properties of the murine aorta. Full-field biaxial data are collected using a pano

SUBMITTER: Bersi MR 

PROVIDER: S-EPMC4914807 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature