Possible selection of host folate pathway gene polymorphisms in patients with malaria from a malaria endemic region in North East India.

ABSTRACT:

Background

Recent studies in experimental mice have shown that mild deficiency of methylenetetrahydrofolate reductase (MTHFR) enzyme confers protection against malaria, thus providing an important basis for the hypothesis that MTHFR polymorphism, i.e. C677T, might have been subjected to selection pressure against malaria. The present study was undertaken in a malaria endemic region in North East India to assess whether a similar selection advantage exists for other genes in folate metabolism pathway.

Methods

A total of 401 subjects including 131 symptomatic malaria, 97 asymptomatic malaria and 173 normal healthy controls were analysed for nine polymorphisms (single-nucleotide polymorphisms [SNPs] in eight genes and insertion/deletion in one gene): MTHFR C677T, methionine syn

SUBMITTER: Mirgal D 

PROVIDER: S-EPMC4914876 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature