Metabolomic profiling to dissect the role of visceral fat in cardiometabolic health.

ABSTRACT:

Objective

Abdominal obesity is associated with increased risk of type 2 diabetes (T2D) and cardiovascular disease. The aim of this study was to assess whether metabolomic markers of T2D and blood pressure (BP) act on these traits via visceral fat (VF) mass.

Methods

Metabolomic profiling of 280 fasting plasma metabolites was conducted on 2,401 women from TwinsUK. The overlap was assessed between published metabolites associated with T2D, insulin resistance, or BP and those that were identified to be associated with VF (after adjustment for covariates) measured by dual-energy X-ray absorptiometry.

Results

In addition to glucose, six metabolites were strongly associated with both VF mass and T2D: lactate and branched-chain amino acids, all of them related to metabolism a

SUBMITTER: Menni C 

PROVIDER: S-EPMC4914926 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature