Ontology highlight
ABSTRACT:
SUBMITTER: Kageyama H
PROVIDER: S-EPMC4914964 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Kageyama Haruaki H Shiba Kanako K Hirako Satoshi S Wada Nobuhiro N Yamanaka Satoru S Nogi Yukinori Y Takenoya Fumiko F Nonaka Naoko N Hirano Tsutomu T Inoue Shuji S Shioda Seiji S
Scientific reports 20160621
Galanin-like peptide (GALP) has an anti-obesity effect in rats and mice. It has been reported that the uptake of GALP by the brain is higher after intranasal administration than with intravenous injection. This study therefore aimed to clarify the effect of intranasal administration of GALP on the feeding behavior of lean and obese mice. Autoradiography revealed the presence of (125)I-GALP in the olfactory bulb and the brain microcirculation. The body weights of ob/ob mice gradually increased du ...[more]