Structural insights of homotypic interaction domains in the ligand-receptor signal transduction of tumor necrosis factor (TNF).

ABSTRACT: Several members of tumor necrosis factor receptor (TNFR) superfamily that these members activate caspase-8 from death-inducing signaling complex (DISC) in TNF ligand-receptor signal transduction have been identified. In the extrinsic pathway, apoptotic signal transduction is induced in death domain (DD) superfamily; it consists of a hexahelical bundle that contains 80 amino acids. The DD superfamily includes about 100 members that belong to four subfamilies: death domain (DD), caspase recruitment domain (CARD), pyrin domain (PYD), and death effector domain (DED). This superfamily contains key building blocks: with these blocks, multimeric complexes are formed through homotypic interactions. Furthermore, each DD-binding event occurs exclusively. The DD superfamily regulates the balance betw

SUBMITTER: Park YH 

PROVIDER: S-EPMC4915230 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature