Abnormal resting state FMRI activity predicts processing speed deficits in first-episode psychosis.

ABSTRACT: Little is known regarding the neuropsychological significance of resting state functional magnetic resonance imaging (rs-fMRI) activity early in the course of psychosis. Moreover, no studies have used different approaches for analysis of rs-fMRI activity and examined gray matter thickness in the same cohort. In this study, 41 patients experiencing a first-episode of psychosis (including N=17 who were antipsychotic drug-naive at the time of scanning) and 41 individually age- and sex-matched healthy volunteers completed rs-fMRI and structural MRI exams and neuropsychological assessments. We computed correlation matrices for 266 regions-of-interest across the brain to assess global connectivity. In addition, independent component analysis (ICA) was used to assess group differences in the expr

SUBMITTER: Argyelan M 

PROVIDER: S-EPMC4915267 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature