Prefrontal thinning affects functional connectivity and regional homogeneity of the anterior cingulate cortex in depression.

ABSTRACT: Major depressive disorder (MDD) is associated with structural and functional alterations in the prefrontal cortex (PFC) and anterior cingulate cortex (ACC). Enhanced ACC activity at rest (measured using various imaging methodologies) is found in treatment-responsive patients and is hypothesized to bolster treatment response by fostering adaptive rumination. However, whether structural changes influence functional coupling between fronto-cingulate regions and ACC regional homogeneity (ReHo) and whether these functional changes are related to levels of adaptive rumination and treatment response is still unclear. Cortical thickness and ReHo maps were calculated in 21 unmedicated depressed patients and 35 healthy controls. Regions with reduced cortical thickness defined the seeds for the subse

SUBMITTER: Spati J 

PROVIDER: S-EPMC4915268 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature