Association of tumor necrosis factor-alpha 308G/A polymorphism with recurrent miscarriages in women.

ABSTRACT:

Background

Recurrent miscarriage (RM) is the most common pregnancy loss in the first trimester affecting approximately 0.5-2% of women. It is a heterogeneous condition and remains an enigma as the underlying cause is still difficult to track down.

Aim

This study was aimed to investigate the distribution of tumor necrosis factor-alpha (TNF-α) 308G/A polymorphism and its association with RM in females. The comparative picture was also demonstrated by comparing genotyping results with healthy control women having no history of miscarriage.

Methods

This clinical study was conducted among 115 women aged 21-44 years with history of recurrence of miscarriage. The samples were collected from women attending the outpatient departments of various hospitals, nursing homes, and i

SUBMITTER: Sudhir N 

PROVIDER: S-EPMC4915291 | biostudies-literature | 2016 Apr-Jun

REPOSITORIES: biostudies-literature