3D genome organization in health and disease: emerging opportunities in cancer translational medicine.

ABSTRACT: Organizing the DNA to fit inside a spatially constrained nucleus is a challenging problem that has attracted the attention of scientists across all disciplines of science. Increasing evidence has demonstrated the importance of genome geometry in several cellular contexts that affect human health. Among several approaches, the application of sequencing technologies has substantially increased our understanding of this intricate organization, also known as chromatin interactions. These structures are involved in transcriptional control of gene expression by connecting distal regulatory elements with their target genes and regulating co-transcriptional splicing. In addition, chromatin interactions play pivotal roles in the organization of the genome, the formation of structural variants, reco

SUBMITTER: Babu D 

PROVIDER: S-EPMC4915485 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature