Reirradiation using robotic image-guided stereotactic radiotherapy of recurrent head and neck cancer.

ABSTRACT: The purpose of this study was to examine the prognosis for patients with head and neck cancer after reirradiation using Cyberknife stereotactic body irradiation with special focus on mucosal ulceration. We conducted a retrospective multi-institutional review of 107 patients with previously irradiated head and neck cancer. The median follow-up time for all patients was 15 months, and the 2-year overall survival rate was 35%. Significant prognostic factors for overall survival were primary site (nasopharynx versus other sites), presence of ulceration, and PTV volume. Detailed analysis of ulceration showed a lower response rate (28%) in the ulceration (+) group than the ulceration (-) group (63%; P = 0.0045). The 2-year overall survival rates were 8% in the ulceration (+) group and 42.7% (P =

SUBMITTER: Yamazaki H 

PROVIDER: S-EPMC4915543 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature