Within-Sulfonylurea-Class Evaluation of Time to Intensification with Insulin (ZODIAC-43).

ABSTRACT:

Background

Previous studies have shown that many within-class differences exist between sulfonylureas (SUs), however, whether differences exist regarding the time it takes between initiating an SU and the need to intensify treatment with insulin is unclear. The aim of this study was investigate the relationships between the three frequently used sulphonylureas, prescribed as dual therapy next to metformin, and the time needed to treatment intensification with either insulin or oral triple therapy in patients with type 2 diabetes mellitus.

Methods

Zwolle Outpatient Diabetes project Integrating Available Care (ZODIAC) is a prospective observational cohort study set in primary care in the Netherlands. Annually collected data on diabetes medication and clinical variables within

SUBMITTER: Schrijnders D 

PROVIDER: S-EPMC4915672 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature