Modelling the Innate Immune Response against Avian Influenza Virus in Chicken.

ABSTRACT: At present there is limited understanding of the host immune response to (low pathogenic) avian influenza virus infections in poultry. Here we develop a mathematical model for the innate immune response to avian influenza virus in chicken lung, describing the dynamics of viral load, interferon-α, -β and -γ, lung (i.e. pulmonary) cells and Natural Killer cells. We use recent results from experimentally infected chickens to validate some of the model predictions. The model includes an initial exponential increase of the viral load, which we show to be consistent with experimental data. Using this exponential growth model we show that the duration until a given viral load is reached in experiments with different inoculation doses is consistent with a model assuming a linear relationship betwe

SUBMITTER: Hagenaars TJ 

PROVIDER: S-EPMC4915690 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature