Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?

ABSTRACT: Cardiac electrophysiology models have been developed for over 50years, and now include detailed descriptions of individual ion currents and sub-cellular calcium handling. It is commonly accepted that there are many uncertainties in these systems, with quantities such as ion channel kinetics or expression levels being difficult to measure or variable between samples. Until recently, the original approach of describing model parameters using single values has been retained, and consequently the majority of mathematical models in use today provide point predictions, with no associated uncertainty. In recent years, statistical techniques have been developed and applied in many scientific areas to capture uncertainties in the quantities that determine model behaviour, and to provide a distribut

SUBMITTER: Johnstone RH 

PROVIDER: S-EPMC4915860 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature