Greater skeletal muscle fat infiltration is associated with higher all-cause mortality among men of African ancestry.

ABSTRACT:

Background

fat infiltration within and around skeletal muscle (i.e. myosteatosis) increases with ageing, is greater in African versus European ancestry men and is associated with poor health. Myosteatosis studies of mortality are lacking, particularly among African ancestry populations.

Methods

in the Tobago Health study, a prospective longitudinal study, we evaluated the association of all-cause mortality with quantitative computed tomography (QCT) measured lower leg myosteatosis (intermuscular fat (IM fat) and muscle density) in 1,652 African ancestry men using Cox proportional hazards models. Date of death was abstracted from death certificates and/or proxy.

Results

one hundred and twelve deaths occurred during follow-up (mean 5.9 years). In all men (age range 40-9

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC4916343 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature