Expanded Glucose Import Capability Affords Staphylococcus aureus Optimized Glycolytic Flux during Infection.

ABSTRACT: Acquisition of numerous virulence determinants affords Staphylococcus aureus greater pathogenicity than other skin-colonizing staphylococci in humans. Additionally, the metabolic adaptation of S. aureus to nonrespiratory conditions encountered during infection (e.g., hypoxia, nitric oxide, iron chelation) has been implicated as contributing to S. aureus virulence. Specifically, S. aureus has been shown to ferment glycolytic substrates in nonrespiratory environments encountered within the host. Here, we show that S. aureus has acquired unique carbohydrate transporters that facilitate the maximal uptake of host sugars and serve to support nonrespiratory growth in inflamed tissue. The carbohydrate substrates of 11 S. aureus transporters were identified, and at least four of their genes encode

SUBMITTER: Vitko NP 

PROVIDER: S-EPMC4916373 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature